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Zappetite 120 Caps by ThermoLife

Zappetite 120 Caps by ThermoLife Zappetite™ – The Ultimate Appetite Suppressant™ is a unique and novel formula containing new ingredients designed to eradicate appetite, burn calories at rest, and increase thermogenesis with NO stimulant side effects. There is no other formula that contains the revolutionary combination of ingredients found in Zappetite.

OEA (Oleoylethanolamide) is a cannabinoid receptor agonist that has been clinically proven to decreases appetite and body weight. Hoodia Gordonii is a plant found in southern Africa containing the P57 compound, which is known for its amazing appetite suppressing activity. Simondslim™ contains Jojoba seed extract standardized for Simmondsin, which has been demonstrated to dramatically decrease appetite and body weight.

LotuSlim™ an ingredient exclusive to Zappetite is a standardized extract of Lotus Leaf, which has been shown to liberate fat stores and decrease body weight. Evodiamine is vanilloid receptor agonist that utilizes the same receptor as the red pepper ingredient capsaicin, which increases body temperature and caloric expenditure. Angelica dhaurica is another ingredient exclusive to Zappetite contains the first standardized extract of imperatorin, which has been shown to act an oxidative uncoupler, increase fat burning hormones and decrease fat storing hormones.

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Sceletium tortuosum is yet another ingredient exclusive to the Zappetite formula. Traditionally know as the “feel good herb” because of its mood enhancing effects sceletium has also been documented for its use in treating relief of the stomach and tooth pains but it was used sparingly because of its “side effect” of a loss of appetite! There is no other formula currently in existence that possesses the appetite crushing and thermogenic properties of Zappetite. ZAPP your appetite away RIGHT NOW with Zappetite!!!

For more information on each of the ground breaking ingredients see below:


Oleyoethanolamide is a naturally occuring amide of oleic acid and ethanolamine,synthesized in the human body primarily by upper part of the small intestine especially when the meal is rich with fats.

It belongs in a family of naturally occurring fatty acid ethanolamides(FAEs), present in both animal and plant organisms[1,2]. It received little attention till it was found that a member of the same family, anandamide, served as an endogenous ligand for cannabinoid receptors(3,4) the G-protein-coupled receptors targeted by Ä9-tetrahydrocannabinol in marijuana [5, 6].

It was found that in the duodenum and jejunum of rats and mice, OEA levels change in response to nutrient status- they are lower in food-deprived than free-feeding animals, and return to normal values upon refeeding [7]. This changes happen in the upper part of the small intestine-the part most associated with food intake and feeding behaviour[8].OEA levels in the rodent small intestine also display diurnal fluctuations. They are higher during the daytime, when animals are satiated, and lower during the night,when they are awake and actively feeding [9]. These findings led researchers conclude that OEA will affect appetite and feeing behaviour. Indeed, studies in mice have shown OEA to suppress appetite in a time and dosage dependent way[10-13]

Apart from it’s appetite suppressing abilities, OEA is also a potent PPAR-á agonist. PPAR-á receptors are a class of nuclear receptors that are also the target for antihyperlipidemic drugs whose stimulation induces increased fatty acid catabolism, lower blood lipid levels and lowered body weight gain[14,15]. In fact, OEA is such a powerful PPAR-á agonist that it’s agonistic action exceeds that of many other PPAR-á agonists[16]. Indeed, apart from it’s antiorexiant actions, OEA has reduced weight when administered chronically to both obese and lean mice.[17] All current data suggests OEA as a very potent compound for the management of appetite and treatment of obesity[16]

Hoodia Gordonii

Hoodia Gordonii is a cactus-like plant from South Africa, from the large Milkweed family. Reports and interviews from South Africa natives suggested that the plant could assuage both the feeling and “pangs” of hunger that occurred during the long treks.[18] Animal studies compromised on extracts from various parts of the plant have shown that Hoodia Gordonii extract can reduce appetite, balance blood sugar levels and promote weight loss, even in overfed animals[19], Animal safety studies have not shown any deleterious side effects independent of the weight loss itself. The putative active component in these sap extracts is a trirhabinoside, known as P57AS3. ZAPPED is currently the only supplement on the market containing Hoodia Gordonii extract that has been tested positive for P57. The mechanism of action of P57 was studied in rats[19]. It was found that P57 increases ATP concentration in the hypothalamus(the part of the brain that among other thing modulates feeding, body temperature, sleep and hormonal release) by 50-150%. It has been found that following long time hypo caloric diets, hypothalamic ATP levels drop by 40-60%, which may very well lead to decreased hormonal production, sleep problems, tiredness e.t.c. Summing up current evidence, apart from the appetite suppression, P57 is very important from combating the side effects following caloric-restricted diets.

Unlike other bogus products on the market, ThermoLife Hoodia tests positive for P57. View our test results (PDF format)


The jojoba plant (Simmondsia chinensis) is a shrub cultivated in arid and semiarid regions for its oil containing nuts. When the leftovers of oil production (jojoba meal) were supplemented to animal food, a profound reduction in food intake was observed. It was demonstrated that simmondsin, a glycoside, was responsible for the appetite-reducing effects of jojoba meal [20]. No major toxic effects have been noted after long-term administration of low doses of simmondsin inducing a sustained food intake and growth reduction in growing rats [21,22]. The food intake-reducing activity seems to be at least in a great part mediated via the vagal nerve since vagotomy significantly reduces the simmondsin-induced food intake inhibition [23]. Further studies on rats have shown the anorectic effects to be dose-dependent, improve with continued simmondsin administration, are greater for overfed rats compared to underfed rats and can also induce taste aversion to craved foods like a saccharin solution[24]. Simmondsin is powerful agent to reduce craving for food.


The Lotus Leaf (Nelumbo nucifera)is a traditional herb, primarily found in India, used for it’s refrigerant, cardiotonic, astringent and liver protecting actions. Studies have also demonstrated that it possesses potent antioxidant,[25], anti-hyperlipidemic[26] and antiviral[27] actions. A study on rats has demonstrated that Lotus Leaf can lower heightened glucose levels, improve glucose tolerance, potentiate insulin activity (both endogenous and exogenous) and reduce glucose absorption [28].

Evodia rutaecarpa

Evodiamine, isolated from the dry unripened fruit of Evodia rutaecarpa Bentham, is used for it’s analgesic,, antiemetic, astringent, and antihypertensive effects in traditional Chinese Herbalism. [29]. Evodiamine also possesses antioxidant and anti-inflammatory activities[30] as well as antianoxic action on oxygen-deprived brain cells[31].

The exact mechanisms of action of Evodiamine are many and still under research. In a study in rats[32], evodiamine demonstrated potent activity as a Cholecystokinine(CCK) agonist. The functions of cholecystokinin (CCK) include stimulation of pancreatic enzyme secretion and inhibition of gastric emptying[33]as well as suppression of food intake [33]. Thus, evodiamine can extend the satiating effect of food by slowing food emptying and reduce overall food intake. Evodiamine also exerts it’s fat loss actions through stimulation of the vallinoid receptors, in the same way as capsaicin.[34] In a study performed on rats , Evodiamine would induce heat loss and heat production at the same time and dissipate food energy, preventing the accumulation of perivisceral fat and the body weight increase.[34]

Angelica Dhaurica

Angelica dahurica Bentham et Hooker (Umbelliferae)is a perennial herb distributed in the whole area of Korea, and its root has been most frequently prescribed as a sedative and an analgesic in Chinese medicine[35]. Angelica species have been traditionally used from the middle ages for various ailments. From various phytochemical studies, it has now been established that the majority of Angelica species contain quite high amounts of biologically active coumarins, predominantly simple- and furano- coumarins like umbelliprenin [36], bergapten, [37] imperatorin [38], isoimperatorin [39], byakangelicin [40], etc., and other active components. Angelica Dhaurica’s furanocumarines imperatorin ,isoimperatorin , and oxypeucedanin are proven to have potent acetylcholynesterase inhibitory activity. Acetylcholynesterase is the enzyme that breaks up the neurotransmitter acetylcholine into acetic acid and choline. Among other things, acetylcholine dilates and relaxes blood vessels, which allows easier removal of fatty acids from adipose cells and also increases c-GMP concentration in fat cells by up to 350% in vitro.[41] Furanocoumarins such as oxypeucedanin hydrate, bergapten, xanthotoxin, imperatorin and phellopterin can also activate adrenalin-induced lipolysis. Imperatorin, oxypeucedanin hydrate and phellopterin also activate ACTH-induced lipolysis. Byakangelicin, neobyakangelicin and isopimpinellin strongly inhibite insulin-stimulated lipogenesis.[42]

Sceletium tortuosum

Sceletium Tortuosum Herba (kougoed) is a traditional herb found mainly in the Western and Eastern Cape provinces, from Namaqualand to Montagu. Sceletium species have been shown to contain at least 9 indole alkaloids, belonging to one of three structural types. In S. tortuosum (1-1.5% alkaloids) mesembrine appears to be most abundant (0.3% and 0.86% have been reported, respectively, in leaf and stem). Mesembrenone and 4’-O-demethylmesembrenol are also present. Tortuosamine, also isolated from S. tortuosum, represents a second structural type in which the pyrrole ring is opened. Alkaloid levels appear to fluctuate seasonally and may be highest in late spring/early summer; this is the time when plants are traditionally gathered and prepared for use [44]

There are many reports in the literature concerning the activity and use of 'kougoed' by the indigenous peoples.' One of the most reputed “side effects” (considered negative by the indigenous people) was loss of appetite [45]. Other traditional uses include use for relief of stomach and tooth pains, sedative, mood enhancement and thirst/hunger suppression. [46]

Zappetite Supplement Facts

Serving Size: 2 Caps
Servings Per Container: 60

Active Ingredients Amount Per Serving
The amazing Zappetite blend:
OEA (Oleoylethanolamide) Hoodia Gordonii (aerial parts) Test positive for P57! Slimondslim (Jojoba seed standardized for 15% Simmondsin) LotuSlim Lotus Leaf extract (Standardized for 20% flavones and alkaloids) Evodia rutaecarpa (fruit) (Standardized for 20% Evodiamine) Angelica Dhaurica (root) (Standardized for 5% imperatorin) Sceletium tortuosum (leaves)

Zappetite Suggested Use

As an adult dietary supplement for weight loss and appetite suppression take 2 capsules twice daily with 12 ounces of water preferably in between meals.